Catsper2^tm1Gar
Targeted Allele Detail

Summary

• Symbol: Catsper2^tm1Gar
• Name: cation channel, sperm associated 2; targeted mutation 1, David L Garbers
• MGI ID: MGI:2683843
• Synonyms: CatSper2-
• Gene: Catsper2 Location: Chr2:121223112-121244273 bp, - strand Genetic Position: Chr2, 60.38 cM
• Alliance: Catsper2^tm1Gar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86972
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment encompassing exons 2 through 5. The deleted region included the start codon and encoded the first three transmembrane helices. Protein was undetected in homozygous mutant mice by Western blot and immunocytochemical analyses of spermatozoa. (J:86972)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Catsper2 Mutation: 36 strains or lines available

References

• Original: J:86972 Quill TA, et al., Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14869-74
• All: 5 reference(s)