Plxnc1^tm1Alk
Targeted Allele Detail

Summary

• Symbol: Plxnc1^tm1Alk
• Name: plexin C1; targeted mutation 1, Alex L Kolodkin
• MGI ID: MGI:2683882
• Synonyms: plexinC1^-
• Gene: Plxnc1 Location: Chr10:94626728-94780697 bp, - strand Genetic Position: Chr10, 49.09 cM, cytoband C3
• Alliance: Plxnc1^tm1Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was inserted into exon 1 downstream of the start codon. Immunohistochemical analysis of pituitary sections indicated an absence of protein in homozygous mutant mice. The absence of functional protein produced by this allele was further supported by flow cytometric analysis of splenic cells. (J:87191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxnc1 Mutation: 80 strains or lines available

References

• Original: J:87191 Pasterkamp RJ, et al., Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405
• All: 11 reference(s)