Itpkc^tm1Ssch
Targeted Allele Detail

Summary

• Symbol: Itpkc^tm1Ssch
• Name: inositol 1,4,5-trisphosphate 3-kinase C; targeted mutation 1, Stephane Schurmans
• MGI ID: MGI:2683901
• Gene: Itpkc Location: Chr7:26906595-26928042 bp, - strand Genetic Position: Chr7, 15.85 cM
• Alliance: Itpkc^tm1Ssch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86257
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.1 kb of the first coding exon was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant by RT-PCR analysis of testis mRNA. (J:86257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itpkc Mutation: 32 strains or lines available

References

• Original: J:86257 Pouillon V, et al., Inositol 1,3,4,5-tetrakisphosphate is essential for T lymphocyte development. Nat Immunol. 2003 Nov;4(11):1136-43
• All: 2 reference(s)