Siah2^tm1Ddlb
Targeted Allele Detail

Summary

• Symbol: Siah2^tm1Ddlb
• Name: siah E3 ubiquitin protein ligase 2; targeted mutation 1, David D L Bowtell
• MGI ID: MGI:2683932
• Synonyms: Siah ^-/-
• Gene: Siah2 Location: Chr3:58582359-58599821 bp, - strand Genetic Position: Chr3, 28.68 cM
• Alliance: Siah2^tm1Ddlb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86820
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 4. This was expected to result in truncation of the protein product at amino acid residue 180. Northern blot analysis confirmed the abolition of gene transcription. (J:86820)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siah2 Mutation: 22 strains or lines available

References

• Original: J:86820 Frew IJ, et al., Generation and analysis of Siah2 mutant mice. Mol Cell Biol. 2003 Dec;23(24):9150-61
• All: 18 reference(s)