Sysbp1^BPL/1J
QTL Variant Detail

Summary

• QTL variant: Sysbp1^BPL/1J
• Name: systolic blood pressure 1; BPL/1J
• MGI ID: MGI:2684031
• QTL: Sysbp1 Location: Chr10:10108265-87401095 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 34.83 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: BPL/1J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased systolic blood pressure compared to BPH/2J. (J:86760)
• Inheritance: Other (see notes)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Sysbp1^BPL/1J/Sysbp1^BPL/1J	involves: BPL/1J * BPH/2J
ht2	Sysbp1^BPH/2J/Sysbp1^BPL/1J	involves: BPL/1J * BPH/2J

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
cardiovascular system	√	√
increased systemic arterial blood pressure	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Sysbp1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:86760

Three different mouse crosses were used to map QTLs associated with systolic blood pressure. Genome scan was performed using 91 - 95 markers at an average spacing of 16 cM. The mouse populations used were a (BPH/2J x BPL/1J)F2 intercross (n=247), an (M. spretus x BPL/1J)F1 x BPL/1J backcross (n=92), and an (M. spretus x BPL/1J)F1 x M. spretus backcross (n=84). Parental strain BPL/1J exhibits low blood pressure whereas parental strains M. spretus and BPH/2J exhibit high blood pressure.

Significant linkage to systolic blood pressure, Sysbp1, mapped to 35 cM (D10Mit20) on mouse Chromosome 10 with LOD=4.4 between D10Mit123 (4 cM) and D10Mit117 (48 cM). This locus was identified in the (BPH/2J x BPL/1J)F2 intercross. BPL/1J-derived alleles confer additivelyinheriteddecrease in systolic blood pressure at Sysbp1.

A second locus exhibiting significant linkage to systolic blood pressure, Sysbp2, mapped to 16 cM (D13Mit198) on mouse Chromosome 13 with LOD=3.3 between D13Mit16 (10 cM) and D13Mit186 (36 cM). This locus was identified in the (M. spretus x BPL/1J)F1 x M. spretus backcross. BPL/1J-derived alleles confer increased blood pressure at Sysbp2. A possible candidate gene mapping to this region is Agtr1a.

Suggestive linkage to systolic blood pressure mapped to 16 cMon mouse Chromosome 8 (LOD=3.2 at D8Mit64), 20 cM and 52.5 cM on mouse Chromosome 2 (LOD=3.1 between D2Mit149 and D2Mit92; LOD=3.2 at D2Mit92, respectively), 74 cM on mouse Chromosome 6 (LOD=2.5 at D6Mit15), and to 16 cM on mouse Chromosome 18 (LOD=2.3 at D18Mit60).

Suggestive linkage to pulse rate mapped to 14 cM on mouse Chromosome 3 (LOD=4.2 between D3Mit60 and D3Mit22), 75 cM on mouse Chromosome 13 (LOD=2.8 at D13Mit78), 19.5 cM on mouse Chromosome 14 (LOD=3.5 at D14Mit19), 66 cM on mouse Chromosome9 (LOD=2.8 between D9Mit81 and D9Mit52), 44 cM on mouse Chromosome 18 (LOD=2.5 at D18Mit103), and to 62 cM on mouse Chromosome X (LOD=2.6 at DXMit35).

References

• Original: J:86760 Wright FA, et al., Genome scan for blood pressure loci in mice. Hypertension. 1999 Oct;34(4 Pt 1):625-30
• All: 1 reference(s)