Sp8^tm1Smb
Targeted Allele Detail

Summary

• Symbol: Sp8^tm1Smb
• Name: trans-acting transcription factor 8; targeted mutation 1, Sheila M Bell
• MGI ID: MGI:2684070
• Synonyms: Sp8^-
• Gene: Sp8 Location: Chr12:118810064-118816311 bp, + strand Genetic Position: Chr12, 63.48 cM
• Alliance: Sp8^tm1Smb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86196
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The majority of the coding region, including the zinc finger domain, was deleted via cre mediated recombination of loxP sites in intron 2 and in the 3' untranslated region. (J:86196)

Expression

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp8 Mutation: 29 strains or lines available

References

• Original: J:86196 Bell SM, et al., Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12195-200
• All: 9 reference(s)