Itga4^tm1Tpa
Targeted Allele Detail

Summary

• Symbol: Itga4^tm1Tpa
• Name: integrin alpha 4; targeted mutation 1, Thalia Papayannopoulou
• MGI ID: MGI:2684111
• Synonyms: alpha4^f, alpha4^flox
• Gene: Itga4 Location: Chr2:79085770-79163467 bp, + strand Genetic Position: Chr2, 47.38 cM
• Alliance: Itga4^tm1Tpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86861
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin cassette was inserted in the promoter and an additional loxP site was placed distal to the second exon. Protein product was expressed at the same levels seen in wild-type mice. (J:86861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga4 Mutation: 62 strains or lines available

References

• Original: J:86861 Scott LM, et al., Deletion of alpha4 integrins from adult hematopoietic cells reveals roles in homeostasis, regeneration, and homing. Mol Cell Biol. 2003 Dec;23(24):9349-60
• All: 28 reference(s)