Nkx1-1^tm1Tlu
Targeted Allele Detail

Summary

• Symbol: Nkx1-1^tm1Tlu
• Name: NK1 homeobox 1; targeted mutation 1, Thomas Lufkin
• MGI ID: MGI:2684149
• Gene: Nkx1-1 Location: Chr5:33588078-33591320 bp, - strand Genetic Position: Chr5, 17.65 cM
• Alliance: Nkx1-1^tm1Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86868
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence at the end of exon 2 and at the beginning of intron 2 was replaced with an IRES-lacZ and floxed neomycin resistance gene. This results in the production of a truncated, non functional protein. (J:86868)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx1-1 Mutation: 13 strains or lines available

References

• Original: J:86868 Simon R, et al., Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
• All: 3 reference(s)