Mcl1^tm2Sjk
Targeted Allele Detail

Summary

• Symbol: Mcl1^tm2Sjk
• Name: myeloid cell leukemia sequence 1; targeted mutation 2, Stanley J Korsmeyer
• MGI ID: MGI:2684150
• Synonyms: Mcl1-bGeo, Mcl-1^null
• Gene: Mcl1 Location: Chr3:95566099-95570487 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Mcl1^tm2Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86906
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence fragment extending from within exon 1 through a 5' portion of exon 2 was replaced with an IRES-betageo cassette. Western blot analysis of mutant murine embryonic fibroblasts indicated that no normal protein is produced from this allele. (J:86906)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcl1 Mutation: 35 strains or lines available

References

• Original: J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
• All: 3 reference(s)