Mcl1^tm3Sjk
Targeted Allele Detail

Summary

• Symbol: Mcl1^tm3Sjk
• Name: myeloid cell leukemia sequence 1; targeted mutation 3, Stanley J Korsmeyer
• MGI ID: MGI:2684151
• Synonyms: F-Mcl-1, Mcl-1^f, Mcl-1^flox
• Gene: Mcl1 Location: Chr3:95566099-95570487 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Mcl1^tm3Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86906
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Single loxP sites flank exon 1, which contains the start codon. Western blot analysis of lysates of thymocytes showed the level of protein in mutant mice to be comparable to that in wild-type mice. (J:86906)

Expression

In Mice Carrying this Mutation:	42 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcl1 Mutation: 35 strains or lines available

References

• Original: J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
• All: 49 reference(s)