Med1^tm1.1Mpk
Targeted Allele Detail

Summary

• Symbol: Med1^tm1.1Mpk
• Name: mediator complex subunit 1; targeted mutation 1.1, Malcom G Parker
• MGI ID: MGI:2684191
• Synonyms: TRAP220^-
• Gene: Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Med1^tm1.1Mpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86857
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was derived from Pparbp^tm1Mpk by transient transfection of properly targeted ES cells with a cre expression vector. This result in the excision of the neomycin gene and both exons 1 and 2. (J:86857)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med1 Mutation: 83 strains or lines available

References

• Original: J:86857 Landles C, et al., The Thyroid Hormone Receptor-Associated Protein TRAP220 Is Required at Distinct Embryonic Stages in Placental, Cardiac, and Hepatic Development. Mol Endocrinol. 2003 Dec;17(12):2418-35
• All: 1 reference(s)