Akap4^tm1Eddy
Targeted Allele Detail

Summary

• Symbol: Akap4^tm1Eddy
• Name: A kinase anchor protein 4; targeted mutation 1, Edward M Eddy
• MGI ID: MGI:2684287
• Gene: Akap4 Location: ChrX:6933758-6944848 bp, + strand Genetic Position: ChrX, 3.17 cM
• Alliance: Akap4^tm1Eddy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86899
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was deleted via cre-mediated recombination of flanking loxP sites. Protein was undetected in homozygous mice by Western blot analysis of testis tissue and epididymal sperm. (J:86899)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap4 Mutation: 2 strains or lines available

References

• Original: J:86899 Miki K, et al., Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol. 2002 Aug 15;248(2):331-42
• All: 2 reference(s)