F13a1^tm1Gdi
Targeted Allele Detail

Summary

• Symbol: F13a1^tm1Gdi
• Name: coagulation factor XIII, A1 subunit; targeted mutation 1, Gerhard Dickneite
• MGI ID: MGI:2684302
• Synonyms: FXIII^-, FXIII-A-
• Gene: F13a1 Location: Chr13:37051152-37234220 bp, - strand Genetic Position: Chr13, 14.44 cM
• Alliance: F13a1^tm1Gdi page

Altered response to myocardial infraction in F13a1^tm1Gdi/F13a1^tm1Gdi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87293
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb fragment encompassing exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. Both coagulation factor XIII enzymatic activity and fibrin gamma-dimerization were undetected in plasma from homozygous mutant mice. (J:87293)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F13a1 Mutation: 48 strains or lines available

References

• Original: J:87293 Lauer P, et al., Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb Haemost. 2002 Dec;88(6):967-74
• All: 19 reference(s)