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Symbol: |
Gt(ROSA)26Sortm1(Notch1)Dam |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas A Melton |
MGI ID: |
MGI:2684314 |
Synonyms: |
Lox-stop-Lox-RosaNICD-ires-GFP, R26fN1-ICD, R26fsN1ICD, R26N1ICD, R26-NICD, R26NotchIC, R-NICD, Rosa26LSL-NICD, Rosa26N1ICD, Rosa26NIC, Rosa26NotchIC-IRES-GFP, Rosa26-StopFloxed-NICD, RosaICNLSL, RosaN1-IC, RosaNICD, ROSA-NICD, RosaNICD1, RosaNICDflox, RosaNotch, Rosa-NotchIC-IRES-GFP, TGNICDflox |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(Notch1)Dam page
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Germline Transmission: |
Earliest citation of germline transmission:
J:86975
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Parent Cell Line: |
AK7 (ES Cell)
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Strain of Origin: |
129S4/SvJaeSor
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(Notch1)Dam expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Notch1 (MGI:97363) |
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Mutation details: A targeting vector containing a floxed neo cassette followed by a mouse Notch1 sequence fragment and GFP was inserted at the endogenous locus. Excision of the floxed neo cassette leads to the expression of the Notch1 sequence encoding an intracellular portion of NOTCH1 (amino acids 1749-2293), but lacking the c-terminal PEST domain. IRES preceded the sequence encoding the nuclear-localized enhanced GFP.
(J:86975)
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View phenotypes and curated references for all genotypes (concatenated display).
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Phenotypic Similarity to Human Syndrome: Liposarcoma, Dedifferentiated J:237232 in double Gt(ROSA)26Sor tm1(Notch1)Dam and Tg(Adipoq-cre)1Evdr mutants.
Phenotypic Similarity to Human Syndrome: Osteosclerosis J: 233131 in double Gt(ROSA)26Sortm1(Notch1)Dam and Tg(Col1a1-cre)1Kry mutants.
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Original: |
J:86975 Murtaugh LC, et al., Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14920-5 |
All: |
234 reference(s) |
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