Tg(Pdx1-cre)89.1Dam
Transgene Detail

Summary

• Symbol: Tg(Pdx1-cre)89.1Dam
• Name: transgene insertion 89.1, Douglas A Melton
• MGI ID: MGI:2684317
• Synonyms: Pdx1^5.5-Cre, Pdx1-Cre, Pdx1Cre, Pdx1-Cre^early, Pdx1-Cre^tg, Pdx1^Tg-Cre, PDX-cre, pPdx1-Cre, Tg(Ipf1-cre)89.1Dam
• Transgene: Tg(Pdx1-cre)89.1Dam Location: unknown
• Alliance: Tg(Pdx1-cre)89.1Dam page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pdx1-cre)89.1Dam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdx1 (MGI:102851)

• Mutation details: Sequence encoding cre recombinase was adjoined to a mouse 5.5 kb region containing Pdx1 regulatory sequences. This promoter drives expression of cre recombinase in the pancreas. Expression was observed in the acini, islets, and ducts but not in mesenchymal cells (endothelial and mesenchyme-derived smooth muscle cells). Robust cre expression can be detected by E10.5 in pancreatic epithelium. (J:76095)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (mouse) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities Alliance mouse Pdx1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

115 assay results 11 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pdx1-cre)89.1Dam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
• All: 224 reference(s)