Tg(Pdx1-cre/Esr1*)35.10Dam
Transgene Detail

Summary

• Symbol: Tg(Pdx1-cre/Esr1*)35.10Dam
• Name: transgene insertion 35.10, Douglas A Melton
• MGI ID: MGI:2684321
• Synonyms: Pdx1^CreERT, Pdx1-Cre-ER^TM, Pdx-creERt2, Tg(Ipf1-cre/Esr1)35.10Dam, Tg(Pdx1-cre/Esr1)35.10Dam
• Transgene: Tg(Pdx1-cre/Esr1*)35.10Dam Location: unknown
• Alliance: Tg(Pdx1-cre/Esr1*)35.10Dam page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pdx1-cre/Esr1*)35.10Dam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pdx1

• Mutation details: Sequence encoding a tamoxifen inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to the Pdx1 promoter to drive mosaic expression of cre recombinase in endocrine, exocrine, and duct tissue of the pancreas. (J:76095)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (species not specified) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
• All: 45 reference(s)