Tg(Neurog3-cre/Esr1*)1Dam
Transgene Detail

Summary

• Symbol: Tg(Neurog3-cre/Esr1*)1Dam
• Name: transgene insertion 1, Douglas A Melton
• MGI ID: MGI:2684324
• Synonyms: Ngn3-Cre, Ngn3/CreER^TM, Tg(Neurog3-cre/Esr1)1Dam
• Transgene: Tg(Neurog3-cre/Esr1*)1Dam Location: unknown
• Alliance: Tg(Neurog3-cre/Esr1*)1Dam page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Neurog3-cre/Esr1*)1Dam expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Neurog3

• Mutation details: The sequence encoding a tamoxifen-inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to a 6.7 kb Neurog3 promoter fragment. The neurogenin 3 promoter drives the expression of cre recombinase in the islet cells of the pancreas. (J:76095)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (species not specified) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
• All: 19 reference(s)