Grhl3^tm1Jane
Targeted Allele Detail

Summary

• Symbol: Grhl3^tm1Jane
• Name: grainyhead like transcription factor 3; targeted mutation 1, Stephen M Jane
• MGI ID: MGI:2684328
• Synonyms: Grhl3-
• Gene: Grhl3 Location: Chr4:135269199-135300941 bp, - strand Genetic Position: Chr4, 67.76 cM
• Alliance: Grhl3^tm1Jane page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86772
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter gene replaced 2.2 kb of endogenous sequence, including exon 2 which encodes the entire transactivation domain. Northern blot and RT-PCR analysis indicated that the allele represents a null mutation. (J:86772)

Expression

In Mice Carrying this Mutation:	125 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grhl3 Mutation: 53 strains or lines available

References

• Original: J:86772 Ting SB, et al., Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nat Med. 2003 Dec;9(12):1513-9
• All: 14 reference(s)