Scgb1a1^tm1Brst
Targeted Allele Detail

Summary

• Symbol: Scgb1a1^tm1Brst
• Name: secretoglobin, family 1A, member 1; targeted mutation 1, Barry R Stripp
• MGI ID: MGI:2684333
• Synonyms: CCSP -
• Gene: Scgb1a1 Location: Chr19:9061006-9065320 bp, - strand Genetic Position: Chr19, 6.05 cM, cytoband A
• Alliance: Scgb1a1^tm1Brst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86895
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin gene was inserted in exon 1 near the 3' end. This results in a truncated protein product. mRNA transcripts were lacking in homozygotes and the absence of protein was confirmed immunologically. (J:86895)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scgb1a1 Mutation: 29 strains or lines available

References

• Original: J:86895 Stripp BR, et al., Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. Am J Physiol. 1996 Oct;271(4 Pt 1):L656-64
• All: 16 reference(s)