Kl^tm1Yin
Targeted Allele Detail

Summary

• Symbol: Kl^tm1Yin
• Name: klotho; targeted mutation 1, Yo-ichi Nabeshima
• MGI ID: MGI:2684400
• Synonyms: kl^-
• Gene: Kl Location: Chr5:150876072-150917282 bp, + strand Genetic Position: Chr5, 89.77 cM, cytoband G3
• Alliance: Kl^tm1Yin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86859
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by homologous recombination of a targeting vector. Protein was undetected in homozygous mutant mice. (J:86859)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kl Mutation: 53 strains or lines available

References

• Original: J:86859 Tsujikawa H, et al., Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403
• All: 6 reference(s)