Hgs^tm1Sug
Targeted Allele Detail

Summary

• Symbol: Hgs^tm1Sug
• Name: HGF-regulated tyrosine kinase substrate; targeted mutation 1, Kazuo Sugamura
• MGI ID: MGI:2684533
• Synonyms: Hgs -
• Gene: Hgs Location: Chr11:120358461-120374805 bp, + strand Genetic Position: Chr11, 84.16 cM
• Alliance: Hgs^tm1Sug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65990
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin selection cassette was inserted into codon 454 such that an HGS-beta-galactosidase fusion protein was expressed from this allele. (J:65990)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgs Mutation: 40 strains or lines available

References

• Original: J:65990 Miura S, et al., Hgs (Hrs), a FYVE domain protein, is involved in smad signaling through cooperation with SARA. Mol Cell Biol. 2000 Dec;20(24):9346-55
• All: 1 reference(s)