Trpv5^tm1Bind
Targeted Allele Detail

Summary

• Symbol: Trpv5^tm1Bind
• Name: transient receptor potential cation channel, subfamily V, member 5; targeted mutation 1, Rene J M Bindels
• MGI ID: MGI:2684536
• Synonyms: TRPV5^-
• Gene: Trpv5 Location: Chr6:41629107-41657703 bp, - strand Genetic Position: Chr6, 19.83 cM
• Alliance: Trpv5^tm1Bind page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 13 was deleted by cre-mediated recombination of flanking loxP sites. A neomycin selection cassette flanked by frt sites remained in intron 12. Immunohistochemical analysis of renal cortex tissue indicated an absence of protein in homozygous mutant mice. (J:86949)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv5 Mutation: 49 strains or lines available

References

• Original: J:86949 Hoenderop JG, et al., Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest. 2003 Dec;112(12):1906-14
• All: 10 reference(s)