Cav3^tm1Ncnp
Targeted Allele Detail

Summary

• Symbol: Cav3^tm1Ncnp
• Name: caveolin 3; targeted mutation 1, Tateki Kikuchi
• MGI ID: MGI:2684578
• Synonyms: cav-3-, cav3 -
• Gene: Cav3 Location: Chr6:112436466-112449833 bp, + strand Genetic Position: Chr6, 52.26 cM, cytoband E1
• Alliance: Cav3^tm1Ncnp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66558
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 0.8 kb of exon 2 through homologous recombination. Northern blot analysis demonstrated that no detectable transcript was expressed in skeletal muscle of homozygous mice, and western blot analysis confirmed that no protein was made from this allele. (J:66558)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cav3 Mutation: 24 strains or lines available

References

• Original: J:66558 Hagiwara Y, et al., Caveolin-3 deficiency causes muscle degeneration in mice. Hum Mol Genet. 2000 Dec 12;9(20):3047-54
• All: 15 reference(s)