Psen1^tm1Vln
Targeted Allele Detail

Summary

• Symbol: Psen1^tm1Vln
• Name: presenilin 1; targeted mutation 1, Fred Van Leuven
• MGI ID: MGI:2684616
• Synonyms: PS1-flox
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm1Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87229
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 7 was flanked by a single loxP site in intron 6 and floxed neo cassette in intron 7. (J:87229)

Disease models

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 48 strains or lines available

References

• Original: J:87229 Dewachter I, et al., Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci. 2002 May 1;22(9):3445-53
• All: 7 reference(s)