Bace1^tm1Cdi
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Cdi
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Colin Dingwall
• MGI ID: MGI:2684825
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Cdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86936
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the first exon was replaced with an IRES-lacZ expression cassette and a PGK-neomycin resistance gene. Western blot analysis demonstrated the absence of protein product. (J:86936)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:86936 Harrison SM, et al., BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci. 2003 Nov;24(3):646-55
• All: 5 reference(s)