Noct^tm1Bjc
Targeted Allele Detail

Summary

• Symbol: Noct^tm1Bjc
• Name: nocturnin; targeted mutation 1, J C Besharse
• MGI ID: MGI:2686733
• Synonyms: Noc^-
• Gene: Noct Location: Chr3:51131868-51159065 bp, + strand Genetic Position: Chr3, 22.12 cM, cytoband B-D
• Alliance: Noct^tm1Bjc page

Noct^tm1Bjc/Noct^tm1Bjc mice exhibit a diet-dependent lean phenotype

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122301
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of exon 3, which contains most of the protein coding sequence including the catalytic domain, was replaced with a neomycin resistance cassette. Absence of protein was confirmed in mutant liver homogenates. (J:122301)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Noct Mutation: 48 strains or lines available

References

• Original: J:122301 Green CB, et al., Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9888-93
• All: 8 reference(s)