About   Help   FAQ
Tg(Rho)1Wbae
Transgene Detail
Summary
Symbol: Tg(Rho)1Wbae
Name: transgene insertion 1, Wolfgang Baehr
MGI ID: MGI:2686794
Synonyms: VPP
Transgene: Tg(Rho)1Wbae  Location: unknown  
Alliance: Tg(Rho)1Wbae page
Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Rho)1Wbae expresses 1 gene
 
Mutation detailsThe transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus. (J:12791)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:12791 Naash MI, et al., Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory