Tg(Rho)1Wbae
Transgene Detail
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Symbol: |
Tg(Rho)1Wbae |
Name: |
transgene insertion 1, Wolfgang Baehr |
MGI ID: |
MGI:2686794 |
Synonyms: |
VPP |
Transgene: |
Tg(Rho)1Wbae Location: unknown
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Alliance: |
Tg(Rho)1Wbae page
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Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice
Show the 1 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6 x SJL
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Rho)1Wbae expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Rho (MGI:97914) |
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Mutation details: The transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus.
(J:12791)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:12791 Naash MI, et al., Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503 |
All: |
16 reference(s) |
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