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Tfap2atm1(cre)Moon
Targeted Allele Detail
Summary
Symbol: Tfap2atm1(cre)Moon
Name: transcription factor AP-2, alpha; targeted mutation 1, Anne M Moon
MGI ID: MGI:2686837
Synonyms: AP2alphaCre, AP2alphaIRES-Cre, AP2alphaIRESCre, AP2-Cre
Gene: Tfap2a  Location: Chr13:40868778-40891852 bp, - strand  Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
Alliance: Tfap2atm1(cre)Moon page
Fourth pharyngeal arch artery aplasia in Tbx1tm2.1Bem/Tbx1+ Tfap2atm1(cre)Moon/Tfap2a+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87304
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tfap2atm1(cre)Moon expression driven by 1 gene
 
Mutation detailsAn IRES-cre cassette followed by an frt-flanked neomycin gene was targeted downstream of the Tcfap2a coding region. The cassette was inserted 198 bp 3' of the stop codon and upstream of the polyadenylation signal. (J:87304)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tfap2a (mouse)
Summary of all recombinase alleles driven by Tfap2a.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)
 
either: (involves: 129/Sv * C57BL/6 * C57BL/6J * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)
 
either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)
 
involves: 129 * C57BL/6J
 
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
 
involves: 129S1/Sv * 129X1/SvJ
 
involves: 129S1/Sv * 129X1/SvJ
 
involves: 129/Sv * C57BL/6
 
involves: 129/Sv * C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
                 
behavior/neurological
N
behavior/neurological phenotype
N
cardiovascular system
abnormal blood vessel morphology
abnormal pharyngeal arch artery morphology
abnormal fourth pharyngeal arch artery morphology
absent fourth pharyngeal arch artery
fourth pharyngeal arch artery hypoplasia
absent sixth pharyngeal arch artery
enlarged third pharyngeal arch artery
abnormal aortic arch morphology
interrupted aortic arch, type b
right aortic arch
abnormal coronary artery morphology
abnormal subclavian artery morphology
aberrant origin of the right subclavian artery
retroesophageal right subclavian artery
abnormal cardiac neural crest cell morphology
abnormal cardiac outflow tract development
persistent truncus arteriosus
double outlet right ventricle
ventricular septal defect
abnormal heart valve morphology
cellular
abnormal neural crest cell apoptosis
craniofacial
abnormal craniofacial morphology
abnormal pharyngeal arch artery morphology
abnormal fourth pharyngeal arch artery morphology
absent fourth pharyngeal arch artery
fourth pharyngeal arch artery hypoplasia
absent sixth pharyngeal arch artery
enlarged third pharyngeal arch artery
absent interparietal bone
abnormal parietal bone morphology
abnormal hyoid bone morphology
abnormal mandible morphology
short mandible
pharyngeal arch hypoplasia
abnormal palate morphology
cleft palate
abnormal tongue muscle morphology
decreased tongue size
digestive/alimentary system
abnormal palate morphology
cleft palate
abnormal tongue muscle morphology
decreased tongue size
embryo
N
embryo phenotype
N
abnormal pharyngeal arch artery morphology
abnormal fourth pharyngeal arch artery morphology
absent fourth pharyngeal arch artery
fourth pharyngeal arch artery hypoplasia
absent sixth pharyngeal arch artery
enlarged third pharyngeal arch artery
abnormal cardiac neural crest cell morphology
abnormal neural crest cell apoptosis
pharyngeal arch hypoplasia
endocrine/exocrine glands
thymus hypoplasia
athymia
growth/size/body
abnormal palate morphology
cleft palate
abnormal tongue muscle morphology
decreased tongue size
hearing/vestibular/ear
abnormal otic capsule morphology
hematopoietic system
thymus hypoplasia
athymia
immune system
thymus hypoplasia
athymia
mortality/aging
neonatal lethality, complete penetrance
postnatal lethality, complete penetrance
prenatal lethality, incomplete penetrance
muscle
abnormal tongue muscle morphology
nervous system
abnormal cardiac neural crest cell morphology
decreased motor neuron number
small trigeminal ganglion
abnormal facial nerve morphology
abnormal trigeminal nerve morphology
abnormal vestibulocochlear nerve morphology
skeleton
absent interparietal bone
abnormal parietal bone morphology
abnormal hyoid bone morphology
abnormal mandible morphology
short mandible
abnormal cartilage morphology
vision/eye
N
vision/eye phenotype
N
decreased cornea thickness
abnormal lens induction
small lens
failure of eyelid fusion
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tfap2a Mutation:  39 strains or lines available
References
Original:  J:87304 Macatee TL, et al., Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003 Dec;130(25):6361-74
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory