Tfap2a^tm1(cre)Moon
Targeted Allele Detail

Summary

• Symbol: Tfap2a^tm1(cre)Moon
• Name: transcription factor AP-2, alpha; targeted mutation 1, Anne M Moon
• MGI ID: MGI:2686837
• Synonyms: AP2alpha^Cre, AP2alpha^IRES-Cre, AP2alpha^IRESCre, AP2-Cre
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^tm1(cre)Moon page

Fourth pharyngeal arch artery aplasia in Tbx1^tm2.1Bem/Tbx1⁺ Tfap2a^tm1(cre)Moon/Tfap2a⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87304
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tfap2a^tm1(cre)Moon expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tfap2a (MGI:104671)

• Mutation details: An IRES-cre cassette followed by an frt-flanked neomycin gene was targeted downstream of the Tcfap2a coding region. The cassette was inserted 198 bp 3' of the stop codon and upstream of the polyadenylation signal. (J:87304)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tfap2a (mouse) Summary of all recombinase alleles driven by Tfap2a. Comparative matrix view of recombinase activities Alliance mouse Tfap2a gene page

Expression

In Mice Carrying this Mutation:

24 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:87304 Macatee TL, et al., Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003 Dec;130(25):6361-74
• All: 29 reference(s)