Del(11Jmjd6-Mettl23)1Flv
Targeted Allele Detail

Summary

• Symbol: Del(11Jmjd6-Mettl23)1Flv
• Name: deletion, Chr 11, Richard A Flavell 1
• MGI ID: MGI:2686850
• Synonyms: Jmjd6^tm1Flv, PSR -
• Gene: Del(11Jmjd6-Mettl23)1Flv Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86771
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(11Jmjd6-Mettl23)1Flv involves 2 genes/genome features (Jmjd6, Mettl23) View all
• Mutation details: The first 2 exons were replaced with a neomycin resistance gene. Absence of expression after this gene modification was confirmed by Northern blot analysis. A subsequent publication demonstrated that the targeting vector also replaced the first exon of the neighboring gene Mettl23, located on the opposite strand. RT-PCR confirmed absence of Mettl23 mRNA in homozygous embryos. (J:86771, J:137989)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(11Jmjd6-Mettl23)1Flv Mutation: 0 strains or lines available

References

• Original: J:86771 Li MO, et al., Phosphatidylserine receptor is required for clearance of apoptotic cells. Science. 2003 Nov 28;302(5650):1560-3
• All: 2 reference(s)