Fgf8^tm1Moon
Targeted Allele Detail

Summary

• Symbol: Fgf8^tm1Moon
• Name: fibroblast growth factor 8; targeted mutation 1, Anne M Moon
• MGI ID: MGI:2686864
• Synonyms: Fgf8^GFP
• Gene: Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
• Alliance: Fgf8^tm1Moon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by single loxP sites inserted by homologous recombination. Sequence encoding GFP was included downstream of the second loxP site, such that after cre-mediated recombination, GFP will be under the control of the Fgf8 gene. (J:87304)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf8 Mutation: 21 strains or lines available

References

• Original: J:87304 Macatee TL, et al., Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003 Dec;130(25):6361-74
• All: 12 reference(s)