Epha4^rb-2J
Spontaneous Allele Detail

Summary

• Symbol: Epha4^rb-2J
• Name: Eph receptor A4; rabbit 2 Jackson
• MGI ID: MGI:2687029
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^rb-2J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: This spontaneous single base pair deletion of adenine at Chr1:77,390,062 bp (GRCm38) in exon 9 results in a frameshift and premature termination, leaving wild-type sequence up to amino acid 582 then seven novel amino acids, before termination, thereby truncating the cytoplasmic sequence before the kinase or SAM domains. (J:267074)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:87289 Cook SA, et al., Two spontaneous mutant alleles, rb and rb-2J, of the Epha4 gene on mouse Chromosome 1. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2004
• All: 3 reference(s)