Urod^tm1Kush
Targeted Allele Detail

Summary

• Symbol: Urod^tm1Kush
• Name: uroporphyrinogen decarboxylase; targeted mutation 1, James P Kushner
• MGI ID: MGI:2687172
• Synonyms: URO-D^-
• Gene: Urod Location: Chr4:116847161-116851561 bp, - strand Genetic Position: Chr4, 53.41 cM
• Alliance: Urod^tm1Kush page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66704
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment encompassing exon 6 and portions of its flanking introns was replaced with a neomycin selection cassette inserted by homologous recombination. (J:66704)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Urod Mutation: 16 strains or lines available

References

• Original: J:66704 Phillips JD, et al., A mouse model of familial porphyria cutanea tarda. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):259-64
• All: 3 reference(s)