Ar^tm1.1Chc
Targeted Allele Detail

Summary

• Symbol: Ar^tm1.1Chc
• Name: androgen receptor; targeted mutation 1.1, Chawnshang Chang
• MGI ID: MGI:2687199
• Synonyms: AR^-, ARKO, GARKO
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1.1Chc page

Immunostaining of androgen receptor and histological analysis of testes of Ar^tm1.1Chc/Y mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81789
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked region including exon 2 was excised from Ar^tm1Chc via cre mediated recombination. Exon 2 encodes the second zinc finger of the DNA-binding domain. (J:81789)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:81789 Yeh S, et al., Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13498-503
• All: 19 reference(s)