Rere^{Gt(PTO26)1Byg}
Gene trapped Allele Detail

Summary

• Symbol: Rere^{Gt(PTO26)1Byg}
• Name: arginine glutamic acid dipeptide (RE) repeats; gene trap PTO26, BayGenomics
• MGI ID: MGI:2687216
• Synonyms: Rere^{Gt(pGT0pfs)1Asp}
• Gene: Rere Location: Chr4:150366103-150706423 bp, + strand Genetic Position: Chr4, 81.34 cM
• Alliance: Rere^{Gt(PTO26)1Byg} page

Mutation origin

• Mutant Cell Line: PT026
• Germline Transmission: Earliest citation of germline transmission: J:87046
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: Gene trap vector pGTO-fs inserted into the gene, included a beta galactosidase gene was inserted in intron 12. Resulting mice express a mutant protein composed of several hundred N-terminal amino acids fused to beta-galactosidase. This is a hypomorphic allele and wild-type mRNA is detectable in homozygotes by RT-PCR. (J:87046)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  PT026	BZ412822 ; (MGI Seq Detail)	5' RACE	Chr4:150594408-150619401 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  173 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rere Mutation: 212 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:87046 Zoltewicz JS, et al., Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development. 2004 Jan;131(1):3-14
• All: 3 reference(s)