Ptpro^tm1Wig
Targeted Allele Detail

Summary

• Symbol: Ptpro^tm1Wig
• Name: protein tyrosine phosphatase receptor type O; targeted mutation 1, Roger C Wiggins
• MGI ID: MGI:2687220
• Synonyms: GLEPP1 knockout, Ptpro^-
• Gene: Ptpro Location: Chr6:137229317-137440231 bp, + strand Genetic Position: Chr6, 66.75 cM
• Alliance: Ptpro^tm1Wig page

Glomeruli podocyte abnormalities in Ptpro^tm1Wig/Ptpro^tm1Wig mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65903
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot and immunofluorescence analyses of homozygous mutant mice, however a polypeptide larger than that produced by the endogenous locus was detected at levels less than 1.2% those of wild-type. (J:65903)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpro Mutation: 122 strains or lines available

References

• Original: J:65903 Wharram BL, et al., Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest. 2000 Nov;106(10):1281-90
• All: 9 reference(s)