Hbnr4^SWR
QTL Variant Detail

Summary

• QTL variant: Hbnr4^SWR
• Name: Heligmosomoides bakeri nematode resistance 4; SWR
• MGI ID: MGI:2687249
• QTL: Hbnr4 Location: Chr1:147125258-188983224 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: SWR

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased mucosal mast cell protease 1 levels compared to CBA. (J:85787)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:85787

500 (SWR x CBA)F2 animals were screened for 175 polymorphic markers to identify QTLs associated with immune response to gastrointestinal nematode infection. Parental strain SWR is resistant to infection by the nematode Heligmosomoides polygyrus compared to susceptible parental strain CBA. Following infection with Heligmosomoides polygyrus, parental strain CBA exhibits increase ganuloma scores (GS), increased IgG1, decreased IgE, and decreased levels of mucosal mast cell protease 1 (MMCP1).

Previously identified QTLs Hpnr1, Hpnr2, and Hpnr3 were detected in this study. Hpnr1 reached LOD=8.4 at 21 cM on mouse Chromosome 1 between D1Mit211 (15 cM) and D1Mit214 (43 cM). SWR-derived alleles confer decreased fecal egg count and total worm count with dominantinheritance at Hpnr1. Hprn2 reached LOD=5.02 at 17 cM on mouse Chromosome 17 between D17Mit29 (15.1 cM) and D17Mit176 (24 cM). SWR-derived alleles confer increased granuloma scores with dominant inheritance at Hnpr2. Hprn3 reached LOD=2.56 at 57 cM on mouse Chromosome 17 between D17Mit93 (50 cM) and D17Mit123 (57 cM). SWR-derived alleles confer increased fecal egg count and total worm count with dominant inheritance at Hnpr3.

The following novel QTL reaching a statistical significant of P>0.01 were identified:

Hpnr4 mapped to 85 cM on mouse Chromosome 1 with LOD=3.07 between D1Mit102 (73 cM) and D1Mit362 (106.3 cM). SWR-derived alleles confer increased MMCP1 levels with recessive inheritance at Hpnr4.

Hpnr5 mapped to 30 cM on mouse Chromosome 2 withLOD=2.79 between D2Mit296 (18 cM) and D2Mit44 (47 cM). SWR-derived alleles confer decreased fecal egg count and total worm count with dominant inheritance at Hpnr5.

Hpnr6 mapped to 44 cM on mouse Chromosome 12 with LOD=4.13 between D12Mit177 (36 cM) andD12Mit194 (45 cM). SWR-derived alleles confer increased in IgE levels with recessive inheritance at Hpnr6.

Hpnr7 mapped to 32 cM on mouse Chromosome 17 with LOD=6.15 between D17Mit176 (22 cM) and D17Mit180 (40.2 cM). SWR-derived alleles confer decreased IgG1 levels with dominant inheritance at Hpnr7.

Hpnr8 mapped to 36 cM on mouse Chromosome 19 with LOD=2.77 between D19Mit88 (34 cM) and D19Mit89 (41 cM). SWR-derived alleles confer decreased fecal egg count and total worm count with dominant inheritanceat Hprn8.

References

• Original: J:85787 Menge DM, et al., Mapping of chromosomal regions influencing immunological responses to gastrointestinal nematode infections in mice. Parasite Immunol. 2003 Jun;25(6):341-9
• All: 1 reference(s)