Pax3^{tm2(PAX3/FOXO1A)Buck}
Targeted Allele Detail

Summary

• Symbol: Pax3^{tm2(PAX3/FOXO1A)Buck}
• Name: paired box 3; targeted mutation 2, Margaret E Buckingham
• MGI ID: MGI:2687304
• Synonyms: Pax3^{Puro(PAX3-FKHR-IRESnLacZ)}
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^{tm2(PAX3/FOXO1A)Buck} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86911
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of exon 1 was replaced with a cassette containing floxed puromycin resistance cassette, sequence encoding a PAX3-FOXO1A hybrid, and lacZ. The presence of the puromycin cassette prevents the expression of both the human PAX3-FOXO1A sequence and lacZ. (J:86911)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:86911 Relaix F, et al., The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo. Genes Dev. 2003 Dec 1;17(23):2950-65
• All: 1 reference(s)