Gadd45b^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Gadd45b^tm1Flv
• Name: growth arrest and DNA-damage-inducible 45 beta; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2687355
• Synonyms: Gadd45b^-
• Gene: Gadd45b Location: Chr10:80765925-80768038 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gadd45b^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87396
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded residues 42 through 161, which make up crucial domains of the protein. (J:87396)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gadd45b Mutation: 12 strains or lines available

References

• Original: J:87396 Lu B, et al., Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells. Nat Immunol. 2004 Jan;5(1):38-44
• All: 15 reference(s)