Cd79a^tm2Pld
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm2Pld
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 2, Roberta Pelanda
• MGI ID: MGI:2687365
• Synonyms: Ig-alpha^-, mb-1^-
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm2Pld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87492
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced by a loxP site, an EGFP gene, a cDNA cassette containing exons 2 - 5 in inverse orientation and a floxed neomycin resistance gene. Lack of mRNA expression was demonstrated by Northern blot analysis. Although designed to be a cre dependent conditional allele capable of expressing either EGFP or Ig-alpha, neither of the inserted genes were ever expressed. (J:87492)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 24 strains or lines available

References

• Original: J:87492 Pelanda R, et al., B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol. 2002 Jul 15;169(2):865-72
• All: 6 reference(s)