Epha4^tm5Kln
Targeted Allele Detail

Summary

• Symbol: Epha4^tm5Kln
• Name: Eph receptor A4; targeted mutation 5, Rudiger Klein
• MGI ID: MGI:3026688
• Synonyms: Epha4^EGFP, Epha4^gf
• Gene: Epha4 Location: Chr1:77343822-77491725 bp, - strand Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
• Alliance: Epha4^tm5Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87398
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of sequence encoding EGFP in frame in exon 3. A truncated protein, in which the cytoplasmic domain was putatively replaced with GFP and thus lacked all intracellular binding sites, was identified in mutant mice by Western blot analysis of hippocampal lysates. (J:87398)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha4 Mutation: 67 strains or lines available

References

• Original: J:87398 Grunwald IC, et al., Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci. 2004 Jan;7(1):33-40
• All: 11 reference(s)