Htatip2^tm1Hx
Targeted Allele Detail

Summary

• Symbol: Htatip2^tm1Hx
• Name: HIV-1 Tat interactive protein 2; targeted mutation 1, Hua Xiao
• MGI ID: MGI:3026855
• Synonyms: Tip30^-
• Gene: Htatip2 Location: Chr7:49408863-49423723 bp, + strand Genetic Position: Chr7, 31.44 cM
• Alliance: Htatip2^tm1Hx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87066
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing lacZ and neo was inserted at the endogenous locus via homologous recombination. The insertion was made 10 codons downstream of the start codon, deleting sequence from 2 exons that encode an N-terminal portion of the exon. Normal transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from liver and stomach tissue. (J:87066)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Htatip2^tm1Hx

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Htatip2 Mutation: 25 strains or lines available

References

• Original: J:87066 Ito M, et al., TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res. 2003 Dec 15;63(24):8763-7
• All: 7 reference(s)