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Abbp1C57BL/6
QTL Variant Detail
Summary
QTL variant: Abbp1C57BL/6
Name: A/J and C57BL/6 blood pressure 1; C57BL/6
MGI ID: MGI:3026899
QTL: Abbp1  Location: Chr1:62946755-120529678 bp  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased blood pressure compared to A/J. (J:86889)
Inheritance:    Other (see notes)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Notes
Abbp1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:86889

Genome scan using 110 microsatellite markers at an average spacing of 15 cM was performed on a population of (A/J x C5BL/6)F2 intercross animals to identify QTLs associated with blood pressure. Parental strain A/J exhibits low blood pressure whereas parental strain C57BL/6 exhibits high blood pressure. A selective genotyping strategy was implemented using F2 animals exhibiting blood pressure greater than 1 standard deviation from the mean.

Abbp1 mapped to mouse Chromosome 1 between 23 cM and 48 cM withpeak linkage to blood pressure between D1Mit303 and D1Mit217 (LOD=6.8) C57BL/6-derived alleles confer increased blood pressure with an additive mode of inheritance at Abbp1. Abbp1 colocalizes with a previously mapped QTL named Bpq1. Human chromosome 2q33-34 is syntenic to the Abbp1 locus.

Abbp2 mapped to mouse Chromosome 4 with peak linkage to blood pressure between D4Mit111 and D4Mit166 (LOD=9.8). C57BL/6-derived alleles confer increased blood pressure at Abbp2 with a recessive mode of inheritance. Abbp2 colocalizes with a previously mapped QTL named Bpq3. Human chromosome 9q31-32 is syntenic to the Abbp2 locus.

Abbp3 (a female-specific QTL) mapped to mouse Chromosome 7 with peak linkage to blood pressure between D7Mit228 and D7Mit37 (LOD=5.4). C57BL/6-derived alleles confer increased blood pressure in female animals at Abbp3 with an additive mode of inheritance. Abbp3 was shown to interact with a locus at D17Mit80 (LRS=38.8).

Abbp4 mapped to mouse Chromosome 11 with peak linkage to blood pressure between D11Mit212 and D11Mit124. C57BL/6-derived alleles confer increased blood pressure at Abbp4 with a recessive mode of inheritance. Candidate genes mapping near Abbp4 include Slc4a1, Car10, Cacnb1, Psa, and Igfbp4. Human chromosome 17q12-23 is syntenic to the Abbp4 locus.

References
Original:  J:86889 Woo DD, et al., Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003 Nov 11;15(3):236-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory