Abbp3^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Abbp3^C57BL/6
• Name: A/J and C57BL/6 blood pressure 3; C57BL/6
• MGI ID: MGI:3026903
• QTL: Abbp3 Location: Chr7:39673887-103510010 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased blood pressure in female animals compared to A/J. (J:86889)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Abbp3 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:86889

Genome scan using 110 microsatellite markers at an average spacing of 15 cM was performed on a population of (A/J x C5BL/6)F2 intercross animals to identify QTLs associated with blood pressure. Parental strain A/J exhibits low blood pressure whereas parental strain C57BL/6 exhibits high blood pressure. A selective genotyping strategy was implemented using F2 animals exhibiting blood pressure greater than 1 standard deviation from the mean.

Abbp1 mapped to mouse Chromosome 1 between 23 cM and 48 cM withpeak linkage to blood pressure between D1Mit303 and D1Mit217 (LOD=6.8) C57BL/6-derived alleles confer increased blood pressure with an additive mode of inheritance at Abbp1. Abbp1 colocalizes with a previously mapped QTL named Bpq1. Human chromosome 2q33-34 is syntenic to the Abbp1 locus.

Abbp2 mapped to mouse Chromosome 4 with peak linkage to blood pressure between D4Mit111 and D4Mit166 (LOD=9.8). C57BL/6-derived alleles confer increased blood pressure at Abbp2 with a recessive mode of inheritance. Abbp2 colocalizes with a previously mapped QTL named Bpq3. Human chromosome 9q31-32 is syntenic to the Abbp2 locus.

Abbp3 (a female-specific QTL) mapped to mouse Chromosome 7 with peak linkage to blood pressure between D7Mit228 and D7Mit37 (LOD=5.4). C57BL/6-derived alleles confer increased blood pressure in female animals at Abbp3 with an additive mode of inheritance. Abbp3 was shown to interact with a locus at D17Mit80 (LRS=38.8).

Abbp4 mapped to mouse Chromosome 11 with peak linkage to blood pressure between D11Mit212 and D11Mit124. C57BL/6-derived alleles confer increased blood pressure at Abbp4 with a recessive mode of inheritance. Candidate genes mapping near Abbp4 include Slc4a1, Car10, Cacnb1, Psa, and Igfbp4. Human chromosome 17q12-23 is syntenic to the Abbp4 locus.

References

• Original: J:86889 Woo DD, et al., Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003 Nov 11;15(3):236-42
• All: 1 reference(s)