Dhcr24^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Dhcr24^tm1Lex
• Name: 24-dehydrocholesterol reductase; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3027024
• Synonyms: Dhcr24-, DHCR24^-, Dhcr24^tm1Fein
• Gene: Dhcr24 Location: Chr4:106418279-106446310 bp, + strand Genetic Position: Chr4, 49.67 cM, cytoband C7
• Alliance: Dhcr24^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87402
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a cassette containing lacZ and neo. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from brain and skin tissue. (J:87402)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dhcr24 Mutation: 35 strains or lines available

References

• Original: J:87402 Wechsler A, et al., Generation of viable cholesterol-free mice. Science. 2003 Dec 19;302(5653):2087
• All: 10 reference(s)