Mre11a^tm1Jpt
Targeted Allele Detail

Summary

• Symbol: Mre11a^tm1Jpt
• Name: MRE11A homolog A, double strand break repair nuclease; targeted mutation 1, John H J Petrini
• MGI ID: MGI:3027036
• Synonyms: Mre11^ATLD1
• Gene: Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
• Alliance: Mre11a^tm1Jpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87088
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: An A-to-T transversion point mutation was engineered at nucleotide 1894 of the coding sequence to recapitulate a nonsense mutation identified in human patients (codon 633). This mutation results in the truncation of 75 amino acids. (J:87088)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mre11a^tm1Jpt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mre11a Mutation: 49 strains or lines available

References

• Original: J:87088 Theunissen JW, et al., Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec;12(6):1511-23
• All: 14 reference(s)