Ceacam1^Hv2-s
Spontaneous Allele Detail

Summary

• Symbol: Ceacam1^Hv2-s
• Name: CEA cell adhesion molecule 1; hepatitis virus (MHV-4) susceptibility
• MGI ID: MGI:3027072
• Synonyms: Ceacam1a
• Gene: Ceacam1 Location: Chr7:25161132-25177028 bp, - strand Genetic Position: Chr7, 13.84 cM
• Alliance: Ceacam1^Hv2-s page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: This allele determines susceptibility to infection by the JHM and A59 strains of mouse hepatitis virus MHV-4, and is found in the strains A/J, C57BL/10, BALB/c, NZB, DBA/2, AKR/J, CBA/J, C3H/He, and SWR and most other inbred strains. (J:3241, J:92495)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ceacam1 Mutation: 45 strains or lines available

Notes

Previously called Mhv-1, Hv2. This locus controls resistance of neurons and macrophages to infection by the JHM and A59 strains of mouse hepatitis virus MHV-4. The allele Ceacam1^Hv2-r determines resistance and has been found only in the SJL/J strain; the strains A/J, C57BL/10, BALB/c, NZB, DBA/2, AKR/J, CBA/J, C3H/He, and SWR are all susceptible to infection (Ceacam1^Hv2-s. Heterozygotes are fully susceptible (J:6451, J:14870, J:7456).

References

• Original: J:701 Dveksler GS, et al., Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J Virol. 1991 Dec;65(12):6881-91
• All: 10 reference(s)