Irgm1^tm1Gat
Targeted Allele Detail

Summary

• Symbol: Irgm1^tm1Gat
• Name: immunity-related GTPase family M member 1; targeted mutation 1, Gregory A Taylor
• MGI ID: MGI:3027112
• Synonyms: Irgm1, LRG-47^-
• Gene: Irgm1 Location: Chr11:48756072-48762247 bp, - strand Genetic Position: Chr11, 28.84 cM, cytoband B1.2
• Alliance: Irgm1^tm1Gat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87535
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 5 kb of genomic sequence were replaced with a neomycin selection cassette inserted by homologous recombination. Included in the deleted region was 0.7 kb of protein coding region. Western blot analysis of MEFs indicated an absence of protein in homozygous mutant mice. (J:87535)

Expression

In Mice Carrying this Mutation:	52018 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irgm1 Mutation: 26 strains or lines available

References

• Original: J:87535 Collazo CM, et al., Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med. 2001 Jul 16;194(2):181-8
• All: 44 reference(s)