Myod1^tm1.1Glh
Targeted Allele Detail

Summary

• Symbol: Myod1^tm1.1Glh
• Name: myogenic differentiation 1; targeted mutation 1.1, David J Goldhamer
• MGI ID: MGI:3027189
• Synonyms: CE^loxP
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^tm1.1Glh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87370
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neo cassette was excised from Myod1^tm1Glh via cre-mediated recombination, leaving a single loxP site in place of the core enhancer. Northern blot analysis indicated that the transcript level was approximately 70% of that observerd in wild-type mice. (J:87370)

Expression

In Mice Carrying this Mutation:

46 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 23 strains or lines available

References

• Original: J:87370 Chen JC, et al., The core enhancer is essential for proper timing of MyoD activation in limb buds and branchial arches. Dev Biol. 2004 Jan 15;265(2):502-12
• All: 4 reference(s)