Itgam^tm1Rws
Targeted Allele Detail

Summary

• Symbol: Itgam^tm1Rws
• Name: integrin alpha M; targeted mutation 1, Richard W Stokes
• MGI ID: MGI:3027319
• Synonyms: CD11b-
• Gene: Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
• Alliance: Itgam^tm1Rws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65847
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 3' and 5' portions of exons 13 and 14, respectively, were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion was expected to preclude the translation of the C-terminal, which includes the majority of the metal-binding domain and the transmembrane domain. (J:65847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgam Mutation: 48 strains or lines available

References

• Original: J:65847 Melo MD, et al., Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of mycobacterium tuberculosis in macrophages. Cell Immunol. 2000 Oct 10;205(1):13-23
• All: 3 reference(s)